diff --git a/changelogs/fragments/80882-Amazon-os-family-compat.yaml b/changelogs/fragments/80882-Amazon-os-family-compat.yaml
new file mode 100644
index 00000000000..cb838736550
--- /dev/null
+++ b/changelogs/fragments/80882-Amazon-os-family-compat.yaml
@@ -0,0 +1,2 @@
+bugfixes:
+- Interpreter discovery - Add ``Amzn`` to ``OS_FAMILY_MAP`` for correct family fallback for interpreter discovery (https://github.com/ansible/ansible/issues/80882).
diff --git a/lib/ansible/module_utils/facts/system/distribution.py b/lib/ansible/module_utils/facts/system/distribution.py
index 6feece2a47e..7cb729d14e0 100644
--- a/lib/ansible/module_utils/facts/system/distribution.py
+++ b/lib/ansible/module_utils/facts/system/distribution.py
@@ -511,7 +511,7 @@ class Distribution(object):
     # keep keys in sync with Conditionals page of docs
     OS_FAMILY_MAP = {'RedHat': ['RedHat', 'RHEL', 'Fedora', 'CentOS', 'Scientific', 'SLC',
                                 'Ascendos', 'CloudLinux', 'PSBM', 'OracleLinux', 'OVS',
-                                'OEL', 'Amazon', 'Virtuozzo', 'XenServer', 'Alibaba',
+                                'OEL', 'Amazon', 'Amzn', 'Virtuozzo', 'XenServer', 'Alibaba',
                                 'EulerOS', 'openEuler', 'AlmaLinux', 'Rocky', 'TencentOS',
                                 'EuroLinux', 'Kylin Linux Advanced Server'],
                      'Debian': ['Debian', 'Ubuntu', 'Raspbian', 'Neon', 'KDE neon',